Tumor-Infiltrating CD3- NK Cells Are More Effective than CD3+ T Cells in Killing Autologous Melanoma Cells
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چکیده
منابع مشابه
Radiosensitivity of CD3 CD8þCD56þ NK cells
The effect of lower doses (0.5e3.0 Gy) of gamma radiation on radiosensitivity of CD3 /CD8þ NK cells subpopulation isolated from the peripheral blood of healthy volunteers was studied 48 h after the irradiation. Only a subtle increase in terms of induction of apoptosis (Aþ cells), was observed in Annexin positive CD3 /CD8þ NK cells. The assessment of the relative presence of CD3 /CD8þ NK cells i...
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NY-ESO-1 is a cancer-testis antigen aberrantly expressed in melanomas, which may serve as a robust and specific target in immunotherapy. NY-ESO-1 antigen expression, tumor features, and the immune profile of tumor infiltrating lymphocytes were assessed in primary cutaneous melanoma. NY-ESO-1 protein was detected in 20% of invasive melanomas (16/79), rarely in in situ melanoma (1/10) and not in ...
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It has been proposed that heterogeneity in natural killer (NK)–cell phenotype and function can be achieved through distinct thymic and bone marrow pathways of NK-cell development. Here, we show a link between Notch signaling and the generation of intracellular CD3 (cyCD3)–expressing NK cells, a cell population that can be detected in vivo. Differentiation of human CD34 cord blood progenitors in...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1991
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12481140